LOWELL A. ERF, M.D., F.A.C.P.; PETER A. HERBUT, M.D.
Myelofibrosis means fibrosis of the bone marrow. The process may be either focal or generalized, primary or secondary, mild or severe, and may or may not be associated with various degrees of myelosclerosis (defined as an excessive proliferation of endosteal bone, known also as osteosclerosis) in any or all bones of the body. Among others, fibrosis of the bone marrow has been observed in the following conditions:
I. Primary (idiopathic),
1. Such a condition has not been described unless Albright's disease1 can be considered as such, or
2. Monomelic medullary osteosclerosis2 (case 1, table 1).
II. Secondary to
ERF LA, HERBUT PA. PRIMARY AND SECONDARY MYELOFIBROSIS (A CLINICAL AND PATHOLOGICAL STUDY OF THIRTEEN CASES OF FIBROSIS OF THE BONE MARROW)1. Ann Intern Med. ;21:863–889. doi: 10.7326/0003-4819-21-5-863
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Published: Ann Intern Med. 1944;21(5):863-889.
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