WARD DARLEY, M.D., F.A.C.P.; ROBERT W. GORDON, M.D., F.A.C.P.; KARL T. NEUBUERGER, M.D.
The recent and exhaustive review by Escamilla and Lisser1 of the literature concerning hypophyseal cachexia (Simmonds' disease) is most timely. From this review it is apparent that confusion regarding the recognition of the syndrome has been very great. The facts that out of 595 reported cases only 101 were proved pathologically and that out of the remaining 494 cases only 158 were typical clinically bear out this contention. As a result of Escamilla's and Lisser's careful analysis of the proved cases, their definition of clinical criteria should lessen the confusion in the recognition of the condition and should serve as
DARLEY W, GORDON RW, NEUBUERGER KT. SIMMONDS' DISEASE WITH THERAPEUTIC RESPONSE TO HORMONE THERAPY FOR FOUR YEARS: REPORT OF A CASE WITH NECROPSY FINDINGS1. Ann Intern Med. ;21:890–902. doi: 10.7326/0003-4819-21-5-890
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Published: Ann Intern Med. 1944;21(5):890-902.
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