S. L. ZIMMERMAN, M.D., Major, M.C, A.U.S.; ROY BARNETT, M.D., Major, M.C., A.U.S.
Real and fancied cardiac disease in sickle cell anemia has been the subject of considerable discussion.1, 2, 3, 4 Particularly has there been confusion with rheumatic fever, as dyspnea, palpitation, cardiac enlargement, systolic and diastolic apical murmurs, and prolonged P-R intervals are associated with arthralgias and fever in both diseases. Klinefelter5 has recently dispelled the confusion. He found cardiac hypertrophy without valvular or endocardial abnormalities, or myocardial damage in all 11 of his autopsied cases of sickle cell anemia. This may be compared with entirely similar findings in 22 of 23 cases of pernicious anemia reported by Cabot.6 In
ZIMMERMAN SL, BARNETT R. SICKLE CELL ANEMIA SIMULATING CORONARY OCCLUSION1. Ann Intern Med. 1944;21:1045–1049. doi: 10.7326/0003-4819-21-6-1045
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Published: Ann Intern Med. 1944;21(6):1045-1049.
Hematology/Oncology, Red Cell Disorders.
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