Since Cushing's original description1 of this symptom complex, the condition has become widely known, doubtless because of the striking and unusual symptoms it presents, in spite of its relative rarity. Cushing attributed the syndrome to a basophilic adenoma of the anterior lobe of the pituitary because this lesion was found in several of the 12 cases he collected. Following his report the syndrome was widely regarded as a manifestation of hyperpituitarism.
Subsequent observations, however, have cast serious doubt on this conclusion. There is no constant relationship between the occurrence of basophilic adenomata and the symptom complex. Many patients with basophilic
CUSHING'S SYNDROME. Ann Intern Med. 1944;21:1050–1052. doi: 10.7326/0003-4819-21-6-1050
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Published: Ann Intern Med. 1944;21(6):1050-1052.
Adrenal Disorders, Endocrine and Metabolism.
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