L. A. JULIANELLE; MORRIS SIEGEL
That sulfonamides exert considerably greater retarding effect on the development of bacteria than viruses, has been too common an experience to require more than passing mention. Consequently, it is not surprising, as previous reports from this laboratory have already indicated,1, 2, 3 that in the administration of sulfadiazine little influence was observed on the incidence and severity of acute respiratory infections presumably of viral etiology. In organizing the clinical studies, therefore, it became important to measure the effects of drug treatment in terms of changes and fluctuations in the bacterial flora of the upper air passages. In the present communication
JULIANELLE LA, SIEGEL M. THE EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTIONS CONDITIONED BY SULFONAMIDES.: II. GROSS ALTERATIONS IN THE NASOPHARYNGEAL FLORA ASSOCIATED WITH TREATMENT1. Ann Intern Med. ;22:10–20. doi: 10.7326/0003-4819-22-1-10
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Published: Ann Intern Med. 1945;22(1):10-20.
Infectious Disease, Pulmonary/Critical Care.
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