L. A. JULIANELLE; MORRIS SIEGEL
In an earlier communication,1 the occasion was taken to comment on the observation that judged by superficial examination, the continual use of sulfadiazine exerted little effect on the frequency of pneumococcus in the throat cultures of physically normal children. It was intimated, however, that underneath the surface this organism was actually participating in a profound process reminiscent of natural selection. It is proposed to submit in the present report a detailed account of the alterations observed and to describe the correlated experiments undertaken to explain their occurrence. The general method employed in handling the children, half under sulfadiazine treatment and
JULIANELLE LA, SIEGEL M. THE EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTIONS CONDITIONED BY SULFONAMIDES.: IV. TRENDS IN PNEUMOCOCCAL TYPES INITIATED BY DRUG TREATMENT1. Ann Intern Med. ;22:29–39. doi: 10.7326/0003-4819-22-1-29
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Published: Ann Intern Med. 1945;22(1):29-39.
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