BERNARD M. SCHOLDER
In 1922 Weil1 first described the syndrome of precocious puberty, fibrocystic bone disease and pigmentation of the skin. Since then there have been reports of some 18 cases.2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 These are presented in table 1. Although the syndrome is interesting because it is uncommon and bizarre, its chief appeal arises from attempts to explain the various phenomena in the light of present day knowledge of neuro-endocrine mechanisms.
The patient to be presented has been under constant medical scrutiny since the onset of symptoms at the age of three, and
SCHOLDER BM. THE SYNDROME OF PRECOCIOUS PUBERTY, FIBROCYSTIC BONE DISEASE AND PIGMENTATION OF THE SKIN: ELEVEN YEARS' OBSERVATION OF A CASE1. Ann Intern Med. ;22:105–118. doi: 10.7326/0003-4819-22-1-105
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Published: Ann Intern Med. 1945;22(1):105-118.
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