ROBERT C. LOWE, M.D., F.A.C.P.; C. C. ADAMS
The subject of sickle cell disease has been rather extensively studied with respect to its clinical1, 2, 3 and pathological4, 5, 6 aspects. Some work7, 8, 9 has been done to study the disease in a dynamic physiologic way, especially with reference to the hemolytic mechanisms and the peculiar pathophysiology of the red blood cells so characteristic of this disease. Inferences are drawn from these studies to explain the terminal histology as well as many of the clinical aspects. Our interest has been centered on fairly long term studies of the pigment metabolism as one of the dynamic mechanisms which
LOWE RC, ADAMS CC. STUDIES ON THE PATHOPHYSIOLOGY OF SICKLE CELL DISEASE1. Ann Intern Med. 1945;22:192–200. doi: 10.7326/0003-4819-22-2-192
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Published: Ann Intern Med. 1945;22(2):192-200.
Hematology/Oncology, Red Cell Disorders.
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