MOSES SALZER, M.D.; J. LOUIS RANSOHOFF, M.D.; BLATT HERMANN, M.D.
About one year ago Wiseman and Doan1 published a report of five cases of "a hitherto unrecognized cause of neutropenia resulting from a pathologically altered, physiologic function of the normal spleen." They labelled this disease "primary splenic neutropenia." They postulated the theory that the spleen has a selective destructive action on the various cellular components of the blood. For instance, in thrombocytopenia, this selective destructive function destroyed the thrombocytes at an abnormally high rate; in hemolytic jaundice the erythrocytes were selected for destruction, whereas in "primary splenic neutropenia" the neutrophiles were the victim of this selective action. In no instance
SALZER M, RANSOHOFF JL, HERMANN B. PRIMARY SPLENIC NEUTROPENIA, WITH REPORT OF A CASE1. Ann Intern Med. ;22:271–273. doi: 10.7326/0003-4819-22-2-271
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Published: Ann Intern Med. 1945;22(2):271-273.
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