M. VIRGINIA PALMER
In the past few years an extensive literature has evolved concerning goitrogens and the goitrogenous state. Some of the results are confusing and some are still of unknown significance, because our knowledge of thyroid physiology is incomplete and the concept of the pituitary-thyroid axis is not thoroughly understood. What causes the thyroid gland to function abnormally, and what is affected by this abnormal function? How exclusive is the importance of the thyroid in Graves' disease, and what is the importance of the pituitary-thyroid axis in relation to the adrenal glands, the hypothalamus and the autonomic nervous system, and
PALMER MV. HYPERTHYROIDISM AND THIOURACIL1. Ann Intern Med. 1945;22:335–364. doi: 10.7326/0003-4819-22-3-335
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Published: Ann Intern Med. 1945;22(3):335-364.
Endocrine and Metabolism, Thyroid Disorders.
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