HARRY FREEDBERG, M.D.
In 1912 Kinnier Wilson described a series of 13 cases of extrapyramidal disease associated with liver cirrhosis. His original description was as follows: "This disease which occurs chiefly in young people, often familial but not congenital or hereditary, is characterized by involuntary movements, dysarthria, muscular weakness, spasticity, contractures, progressive emaciation, mental deterioration and frequent emotional disturbances. This disease is progressive and, after a longer or shorter period, fatal." Since then sporadic cases have been reported in the literature.
Many hypotheses have been advanced as to the etiology of the disease and chief among the reviews has been that of Jervis.
FREEDBERG H. HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE); REPORT OF ONE CASE WITH SEVERE PORTAL CIRRHOSIS AND SPLENOMEGALY1. Ann Intern Med. 1945;22:418–425. doi: 10.7326/0003-4819-22-3-418
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Published: Ann Intern Med. 1945;22(3):418-425.
Encephalopathy, Gastroenterology/Hepatology, Liver Disease, Neurology, Tobacco, Alcohol, and Other Substance Abuse.
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