NORMAN W. DREY
Transient ketonuria in association with aglycosuria observed in insulin treated diabetics presents an apparent paradox. Such an observation was not uncommon at the time protamine zinc insulin was becoming popular. As pointed out by Mirsky1 the older theories concerning ketogenesis are still invoked whenever a clinical problem involving ketonuria is found. The standard texts on diabetes mellitus dwell lightly upon the newer concepts concerning ketogenesis. The significance of insulin induced ketonuria, therefore, is frequently misunderstood and the condition is treated by additional insulin.
In 1935 Somogyi2 observed the "causal connection between hypoglycemia and ketosis." Since this time he has expanded
DREY NW. THE CLINICAL INTERPRETATION OF INSULIN INDUCED KETONURIA1. Ann Intern Med. ;22:811–818. doi: 10.7326/0003-4819-22-6-811
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Published: Ann Intern Med. 1945;22(6):811-818.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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