D. L. BURDICK, M.D.; E. A. ROVENSTINE, M.D.
Picrotoxin as an antidote for human barbiturate poisoning was used first by Arnett1 in 1933. Maloney, Fitch and Tatum2 previously had demonstrated its effectiveness by animal experiments. In 1936 Koppanyi and his co-workers3 definitely established its clinical value and proved its safety when administered properly. During the ensuing years the practical use of picrotoxin has been determined, particularly for those patients having a degree of narcosis approaching lethal levels.
The recent extensive review of the pharmacologic and physiologic aspects of the barbiturate problem by Tatum4 and Richards'5 clinical evaluation of picrotoxin in barbiturate poisoning agree in establishing it as the
BURDICK DL, ROVENSTINE EA. PICROTOXIN IN BARBITURATE POISONING1. Ann Intern Med. ;22:819–826. doi: 10.7326/0003-4819-22-6-819
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Published: Ann Intern Med. 1945;22(6):819-826.
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