SHEPARD SHAPIRO, M.D.; RICHARD K. RICHARDS, M.D., F.A.C.P.
The liver is a most versatile organ. Its activities include various types of cellular physiology, principally synthesis, storage, conjugation, catabolism and excretion. Although subject to humoral influence, the functions, nevertheless, appear to be devoid of interdependence. However, despite the "dissociation,"1 certain of the mechanisms exhibit with significant constancy a higher degree of susceptibility to pathologic change than the others. Recently, Drill and Ivy2 found abnormal retention of bromsulphalein to be the earliest detectable alteration in function following the production of liver damage in dogs by the administration of carbon tetrachloride.
At the time the paper by Drill and Ivy2 appeared
SHAPIRO S, RICHARDS RK. THE PROTHROMBIN RESPONSE TO LARGE DOSES OF SYNTHETIC VITAMIN K IN LIVER DISEASE1. Ann Intern Med. 1945;22:841–851. doi: 10.7326/0003-4819-22-6-841
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Published: Ann Intern Med. 1945;22(6):841-851.
Gastroenterology/Hepatology, Liver Disease.
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