Lymphogranuloma venereum is a disease which presents itself in a number of different clinical types. The infection is usually transmitted by sexual contact, and the presenting lesions are generally located in the genital and perineal region. The indolent ulcerating inguinal buboes (climatic buboes, tropical buboes) commonly seen in men, esthiomène with hypertrophy and ulceration of the labia, and the ano-rectal syndrome with proctitis and rectal stricture, were all recognized and described as distinct clinical entities many years ago. That these were merely different manifestations of the same disease was not realized until Frei1 in 1925 devised his intracutaneous test, utilizing
THE VIRUS OF LYMPHOGRANULOMA VENEREUM. Ann Intern Med. ;22:891–895. doi: 10.7326/0003-4819-22-6-891
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Published: Ann Intern Med. 1945;22(6):891-895.
Infectious Disease, Sexually Transmitted Infections.
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