T. S. DANOWSKI, M.D.; A. W. WINKLER, F.A.C.P.; J. P. PETERS, M.D.
Massive doses of vitamin D have been used in the treatment of arthritis during the past decade.1, 2 Symptoms and physical disabilities of some patients have apparently improved on this régime. The clinical reports have usually implied that the toxic effects of these large doses are insignificant.3, 4, 5, 6, 7 In this report two cases of renal damage secondary to prolonged therapy with vitamin D are described. In one of these extensive calcification of soft tissues was readily demonstrable.
Case 1 (E. S.) This English housewife was first admitted to New Haven Hospital in 1932 at the
DANOWSKI TS, WINKLER AW, PETERS JP. TISSUE CALCIFICATION AND RENAL FAILURE PRODUCED BY MASSIVE DOSE VITAMIN D THERAPY OF ARTHRITIS(TISSUE CALCIFICATION AND RENAL FAILURE PRODUCED BY MASSIVE DOSE VITAMIN D THERAPY OF ARTHRITIS*). Ann Intern Med. 1945;23:22–29. doi: 10.7326/0003-4819-23-1-22
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Published: Ann Intern Med. 1945;23(1):22-29.
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