BERNARD SELIGMAN, M.D., F.A.C.P.; LOUIS NATHANSON, M.D., M.SC. (MED.)
Soft tissue, "metastatic" calcification has been reported in only one previous case of osteitis deformans, which was described by Wells and Holley1 Metastatic calcification is to be distinguished from calcinosis. The former represents calcification of apparently healthy tissue due to changes in the composition of the blood calcium and phosphorus salts, phosphatase, or alkalinity. The latter represents another stage of an underlying pathologic process of certain tissue such as occurs in scleroderma, sclerodactyly, Raynaud's disease, dermatomyositis, progressive lipoid dystrophy, myositis ossificans, etc.2
In a 59 year old man who had Paget's disease for six to seven years and had received
SELIGMAN B, NATHANSON L. "METASTATIC" CALCIFICATION IN SOFT TISSUES OF LEGS IN OSTEITIS DEFORMANS; CASE REPORT("METASTATIC" CALCIFICATION IN SOFT TISSUES OF LEGS IN OSTEITIS DEFORMANS; CASE REPORT*). Ann Intern Med. 1945;23:82–91. doi: 10.7326/0003-4819-23-1-82
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Published: Ann Intern Med. 1945;23(1):82-91.
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