The inactivation of penicillin by the gastric juice, which renders it ordinarily ineffective by mouth, and its rapid excretion in the urine when given by parenteral injection, have given rise to troublesome technical difficulties in its administration. Thus far the most efficient method of maintaining an effective concentration in the blood and the most economical as far as the wastage of drug is concerned is the continuous intravenous drip. The practical disadvantages of this procedure are obvious and have stimulated many attempts to devise some simpler method of administration.
Subcutaneous injections are irritating and painful, and absorption has been reported
METHODS OF ADMINISTERING PENICILLIN. Ann Intern Med. ;23:275–279. doi: 10.7326/0003-4819-23-2-275
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Published: Ann Intern Med. 1945;23(2):275-279.
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