ROBERT C. MURPHY JR., M.D.; SHEPARD SHAPIRO, M.D.
The incidence of the sickle cell trait among North American Negroes has been estimated from various surveys to be 7 per cent,23 7.2 per cent,10 9.1 per cent6a and even as high as 13 per cent1a of the Negro population. Clinical sickle cell disease appears in an undetermined fraction of cases in which the trait is present, estimates of this ratio varying from 1:7 to 1:40.23 As far as can be determined the trait is transmitted as a true Mendelian dominant,12, 15, 23, 33 independent of the inheritance of blood type.23 This apparent fact has been used as an argument
MURPHY RC, SHAPIRO S. THE PATHOLOGY OF SICKLE CELL DISEASE1. Ann Intern Med. 1945;23:376–397. doi: 10.7326/0003-4819-23-3-376
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Published: Ann Intern Med. 1945;23(3):376-397.
Hematology/Oncology, Red Cell Disorders.
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