JESSAMINE R. GOERNER, M.D.; ARTHUR J. GEIGER, M.D.; FRANCIS G. BLAKE, M.D., F.A.C.P.
The attempt to cure subacute bacterial endocarditis with penicillin was a natural sequel to similar earlier efforts with the sulfonamide group of drugs, with which the results had proved successful in sporadic cases.1 Limiting factors in the control of the infection with the sulfonamides have included the resistance of the usual causative organism, the Streptococcus viridans, and the toxicity of the sulfonamide compounds when administered in the large doses and long courses required to achieve prolonged bacteriostatic concentrations in the body. Although the resistance of the Streptococcus viridans to penicillin is generally known to be relatively high as compared with
GOERNER JR, GEIGER AJ, BLAKE FG. TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS WITH PENICILLIN: REPORT OF CASES TREATED WITHOUT ANTICOAGULANT AGENTS1. Ann Intern Med. ;23:491–519. doi: 10.7326/0003-4819-23-4-491
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Published: Ann Intern Med. 1945;23(4):491-519.
Cardiology, Endocarditis, Infectious Disease, Streptococcal Infections.
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