J. L. GABRILOVE, M.D.; M. J. KERT, M.D.; L. J. SOFFER, M.D.
The origin of the use of thiouracil in the treatment of hyperthyroidism stems from the past studies of the mechanism of the production of experimental goiter. During the course of these studies in which the rôle of iodine in the production of simple goiter was convincingly demonstrated, many interesting facts were unearthed that were to be of striking importance in the development of the rationale for the use of thiourea derivatives in the treatment of hyperthyroidism.
In 1928, Chesney and his co-workers1 noted the development of goiter in their stock rabbits fed on a cabbage diet. The thyroid
GABRILOVE JL, KERT MJ, SOFFER LJ. THE USE OF THIOURACIL IN THE TREATMENT OF PATIENTS WITH HYPERTHYROIDISM1. Ann Intern Med. ;23:537–558. doi: 10.7326/0003-4819-23-4-537
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Published: Ann Intern Med. 1945;23(4):537-558.
Endocrine and Metabolism, Thyroid Disorders.
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