This interesting disease was first clearly recognized as a distinct entity by Cooley,1 who described the condition as it occurs in a severe form in children. Although the disease is relatively uncommon, Cooley's observations have been confirmed and amplified by many subsequent observers.
The disease is characterized by an increasing anemia which usually is not notable at birth, but becomes evident during infancy or early childhood and which progresses without remissions and in spite of treatment to a fatal termination within a few years or even a few months. In somewhat milder cases it may not be recognized until the
MEDITERRANEAN ANEMIA. Ann Intern Med. 1945;23:683–686. doi: 10.7326/0003-4819-23-4-683
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Published: Ann Intern Med. 1945;23(4):683-686.
Hematology/Oncology, Red Cell Disorders.
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