JOHN WESLEY SHIRER, M.D.; MORTIMER COHEN, M.D., F.A.C.P.
Since Plummer1 instituted the use of iodine in the preoperative preparation of the thyrotoxic patient in 1923, little has been added to the management of thyroid disease except refinements of technic in the operative procedures. One of the most striking developments in the management of hyperthyroidism has come with the recent advances in chemotherapy. MacKenzie and MacKenzie,2 in 1943, showed that sulphonamide treated animals developed goiters and hypometabolism. Astwood3 sought a substance allied chemically to the sulphonamides which would be less toxic to human beings. After experimentation, he chose thiourea and thiouracil as the chemicals of least toxicity. He reported
SHIRER JW, COHEN M. THE EFFECTS OF THIOURACIL ON THE THYROID GLAND1. Ann Intern Med. ;23:790–799. doi: 10.7326/0003-4819-23-5-790
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Published: Ann Intern Med. 1945;23(5):790-799.
Endocrine and Metabolism, Thyroid Disorders.
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