JANET W. MCARTHUR, M.D.; RULON W. RAWSON, M.D.; J. H. MEANS, M.D., F.A.C.P.
Thiouracil has been employed in the preoperative preparation of 104 patients suffering from thyrotoxicosis at the Massachusetts General Hospital between April 1943 and April 1945. Toxic reactions (applying the term in the most inclusive sense) have occurred in 15 instances. In five cases, fever has been the most conspicuous feature of the reaction. Case reports of three2 of these patients are presented, together with speculations as to the fundamental significance of the idiosyncratic response.
Case 1. E. H., a 40-year-old white married housewife, was admitted on April 8, 1944, complaining of weakness, easy fatigability, nervousness and a sense
MCARTHUR JW, RAWSON RW, MEANS JH. IDIOSYNCRATIC FEBRILE REACTIONS TO THIOURACIL: CLINICAL CHARACTERISTICS AND POSSIBLE PHARMACOLOGIC SIGNIFICANCE1. Ann Intern Med. ;23:915–923. doi: 10.7326/0003-4819-23-6-915
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Published: Ann Intern Med. 1945;23(6):915-923.
Emergency Medicine, Endocrine and Metabolism, Hospital Medicine, Thyroid Disorders.
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