JERRY K. AIKAWA, M.D.
As early as 1886 Haig-Brown observed that an incubation period precedes the development of acute rheumatism following a pharyngeal infection. This period is comparable to that which precedes the development of serum sickness following the administration of serum.
Derick, Hitchcock and Swift,27 in 1928, reported that the administration of acetylsalicylic acid prevents the arthritis of serum sickness, but does not relieve the other symptoms and signs of the disease, as it does in rheumatic fever. The serum of patients treated prophylactically with this drug failed to precipitate horse serum. Untreated patients had a marked rise in
AIKAWA JK. HYPERSENSITIVITY AND RHEUMATIC FEVER. PART II. RELATION OF RHEUMATIC FEVER TO HYPERSENSITIVITY1. Ann Intern Med. ;23:983–1000. doi: 10.7326/0003-4819-23-6-983
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Published: Ann Intern Med. 1945;23(6):983-1000.
Infectious Disease, Rheumatology, Streptococcal Infections.
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