VICTOR H. KUGEL; MAURICE A. SCHNITKER
The variety of agents used to stimulate the bone marrow in neutropenic states has usually produced indifferent (equivocal) results. This has led several investigators to attempt to modify the course of an agranulocytosis by combating the complicating sepsis. According to Dameshek and Wolfson1 "death (in agranulocytosis) is probably the result of overwhelming sepsis in a body stripped of its granulocyte defenses." These authors reasoned that if sepsis could be controlled until such time as spontaneous recovery of function of the bone marrow might take place, a better therapeutic result might occur. They reported two cases of agranulocytosis occurring after aminopyrine
KUGEL VH, SCHNITKER MA. THE VALUE OF PENICILLIN IN THE CONTROL OF SEPSIS COMPLICATING A CASE OF SEVERE GRANULOCYTOPENIA (ALEUKEMIC LEUKEMIA)1. Ann Intern Med. 1945;23:1001–1006. doi: 10.7326/0003-4819-23-6-1001
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Published: Ann Intern Med. 1945;23(6):1001-1006.
Hematology/Oncology, Leukemia/Lymphoma, Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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