ALVAN L. BARACH, M.D., F.A.C.P.; BETTINA GARTHWAITE, M.D.; MAX SOROKA, B.S.; FREDERICK F. ANDERSON
In a preliminary report1 the inhalation of nebulized penicillin in broncho-pulmonary infections was described. In some instances the mist of penicillin was inhaled through the nose with the idea that the sinuses might be in communication with the air in the nasal passages. However, in order to introduce penicillin aerosol into the sinuses, it was finally considered necessary to evacuate air from the sinuses by developing a negative pressure in the nasal passages with immediate replacement of air containing penicillin in high concentrations.23
An apparatus was devised for production of penicillin aerosol with intermittent negative pressure in the nasal and
BARACH AL, GARTHWAITE B, SOROKA M, ANDERSON FF. AN APPARATUS FOR THE INTRODUCTION OF PENICILLIN AEROSOL INTO THE NASAL ACCESSORY SINUSES WITH A CASE REPORT OF A PATIENT WITH CHRONIC SINUSITIS1. Ann Intern Med. ;24:97–103. doi: 10.7326/0003-4819-24-1-97
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Published: Ann Intern Med. 1946;24(1):97-103.
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