I. J. GREENBLATT; T. D. COHN; H. L. DEUTSCH
In an extensive report on Mediterranean target-oval cell syndrome, Dameshek1 proposed the following criteria for its recognition: (a) "The racial factor, (b) a reduction in hemoglobin concentration in association with a low color index, (c) refractoriness to iron therapy, (d) the presence of increased numbers of target cells and reticulocytes, usually in association with oval and stippled red blood corpuscles, (e) the presence of increased hypotonic resistance of the erythrocytes and (f) the absence of such conditions as hepatic disease, steatorrhea, bleeding or lead poisoning." He suggested a probable relationship between this syndrome and Cooley's anemia. It is well known
GREENBLATT IJ, COHN TD, DEUTSCH HL. MEDITERRANEAN TARGET-OVAL CELL SYNDROME IN AN ADULT CHINESE MALE: REPORT OF A CASE1. Ann Intern Med. ;24:259–261. doi: 10.7326/0003-4819-24-2-259
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Published: Ann Intern Med. 1946;24(2):259-261.
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