HILTON S. READ; LAWRENCE I. KAPLAN; FREDERIC T. BECKER; MARK F. BOYD, M.D.
Since the introduction by Wagner-Jauregg1 in 1917 of inoculation malaria in the treatment of neurosyphilis, thousands of patients have received this form of fever therapy. At a recently organized Army Neurosyphilis Center,2 300 patients, 75 per cent of whom had asymptomatic neurosyphilis and were in excellent physical condition, completed courses of 10 to 25 malarial paroxysms during an 11 month period from July 1944 to June 1945. Although racial immunity, previous attacks of natural malaria and the recent return of some patients from hyperendemic areas necessitated a number of reinoculations with heterologous malarial strains, 211 patients finally completed therapy with
READ HS, KAPLAN LI, BECKER FT, BOYD MF. AN ANALYSIS OF COMPLICATIONS ENCOUNTERED DURING THERAPEUTIC MALARIA1. Ann Intern Med. ;24:444–464. doi: 10.7326/0003-4819-24-3-444
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Published: Ann Intern Med. 1946;24(3):444-464.
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