CHARLES M. CARAVATI, F.A.C.P.; EDGAR F. COSGROVE
For years it has been customary to administer alkalis in conjunction with oral salicylate therapy, based on the assumption that sodium bicarbonate protects the stomach by inhibiting the release of salicylic acid.1 However, not until the recent work of Coburn2 has it become customary to administer massive doses of salicylates over a protracted period. He advocates the intravenous and oral administration of sodium salicylate until a blood plasma level of over 300 gammas per c.c. is reached, and recommends that it be maintained at a high level for some weeks. In the application of this therapeutic procedure in our hands,
CARAVATI CM, COSGROVE EF. SALICYLATE TOXICITY: THE PROBABLE MECHANISM OF ITS ACTION(SALICYLATE TOXICITY: THE PROBABLE MECHANISM OF ITS ACTION*). Ann Intern Med. 1946;24:638–642. doi: 10.7326/0003-4819-24-4-638
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Published: Ann Intern Med. 1946;24(4):638-642.
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