ERNEST COTLOVE, M.D.; JEFFERSON J. VORZIMER, M.D., F.A.C.P.
Venous thrombosis with pulmonary embolism has long been recognized as an important and serious complication in postoperative surgical patients. The significance of thromboembolism in medical patients and particularly in those with heart disease is only beginning to gain adequate recognition. Pathological studies1, 2 have shown pulmonary embolism to be the main or contributory cause of death in one-fourth to one-third of patients dying with coronary occlusion or congestive heart failure.
White3 has recently summarized the significance of thromboembolism in heart disease. Pulmonary embolism may simulate heart disease, especially myocardial infarction; it may precipitate a severe anginal attack or even myocardial
COTLOVE E, VORZIMER JJ. SERIAL PROTHROMBIN ESTIMATIONS IN CARDIAC PATIENTS: DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS; USE OF DICUMAROL1. Ann Intern Med. 1946;24:648–665. doi: 10.7326/0003-4819-24-4-648
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Published: Ann Intern Med. 1946;24(4):648-665.
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