RUDOLPH A. KOCHER; WALTER J. SIEMSEN
The majority of patients with diphtheria rid themselves of bacilli within the first two weeks after recovery. However, there remains a fairly large percentage of cases who become carriers and who present a serious danger to the spread of the disease unless isolated or freed of the infecting organism. Heretofore, although a great variety of bactericidal agents has been tried, the treatment of carriers has remained unsatisfactory.
It has previously been shown by Abraham, Chain, et al.1 Chain, Florey et al.,2 and by Fleming,3 that Corynebacterium diphtheriae is susceptible to the action of penicillin in vitro. Because of this fact
KOCHER RA, SIEMSEN WJ. DIPHTHERIA CARRIERS TREATED WITH PENICILLIN1. Ann Intern Med. ;24:883–886. doi: 10.7326/0003-4819-24-5-883
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Published: Ann Intern Med. 1946;24(5):883-886.
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