ROBERT W. HUNTINGTON JR.; ROSALIE D. RYAN; HUGH R. BUTT; GEORGE C. GRIFFITH; HUGH MONTGOMERY; ROBERT F. SOLLEY; WILLIAM H. LEAKE
Although salicylates induce striking symptomatic relief in rheumatic fever, especially in the presence of polyarthritis, the question of a more radical therapeutic action is a debated one. It has recently been suggested1 that while small doses produce symptomatic relief only, large doses have a genuine curative effect. Our own data on this problem are analyzed in detail elsewhere.2 The present paper is concerned with the technic of reaching the plasma or serum salicylate level of 20 to 30 mg. per cent or higher, which Coburn considered critical.
We have studied serum salicylate levels following oral, rectal and intravenous administration
HUNTINGTON RW, RYAN RD, BUTT HR, GRIFFITH GC, MONTGOMERY H, SOLLEY RF, et al. STUDIES IN RHEUMATIC FEVER II. ABSORPTION OF SALICYLATES1. Ann Intern Med. ;24:1029–1038. doi: 10.7326/0003-4819-24-6-1029
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Published: Ann Intern Med. 1946;24(6):1029-1038.
Infectious Disease, Rheumatology, Streptococcal Infections.
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