I. DONALD FAGIN, M.D., F.A.C.P.; EDWARD H. SCHWAB, M.D., F.A.C.P.
Knowledge of the pathology and clinical signs of emphysema of the interstitial tissues of the lung and the mediastinum dates from the time of Laennec, but only during the past decade has it been realized that such emphysema may occur in the absence of thoracic trauma or infection. Full credit is due to Hamman for the recognition and description of mediastinal emphysema of apparently spontaneous origin. In 1934, Hamman1a described three cases of this syndrome, later adding four others.1b, 1c Since that time, the medical literature has included sporadic reports of similar cases. The experimental work of Macklin2 has contributed
I. DONALD FAGIN, EDWARD H. SCHWAB. SPONTANEOUS MEDIASTINAL EMPHYSEMA(SPONTANEOUS MEDIASTINAL EMPHYSEMA*). Ann Intern Med. 1946;24:1052–1072. doi: 10.7326/0003-4819-24-6-1052
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Published: Ann Intern Med. 1946;24(6):1052-1072.
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