EDWIN E. ZIEGLER, M.D., F.A.C.P.
Histoplasmosis is an acute, subacute or chronic; localized or systemic; sporadic, granulomatous, infectious, fatal disease, caused by the fungus, Histoplasma capsulatum. It is spreading quite rapidly or being recognized more frequently, or both.
In 1906, Richard P. Strong1 published a paper on the etiology of some tropical ulcerations of the skin. He found in material curetted from a skin lesion, oval bodies, which resembled cockleshells, with a sharp outline, measuring about three to four micra in diameter; many of them contained particles of chromatin. They were found in large numbers, both free and enclosed in phagocytic endothelioid cells. He wrote,
ZIEGLER EE. HISTOPLASMOSIS OF DARLING: REVIEW AND CASE REPORT WITH AUTOPSY1. Ann Intern Med. ;24:1073–1087. doi: 10.7326/0003-4819-24-6-1073
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Published: Ann Intern Med. 1946;24(6):1073-1087.
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