HAROLD L. HIRSH, M.D.; HARRY F. DOWLING, M.D., F.A.C.P.; LEWIS K. SWEET, M.D.
Penicillin X is a fraction obtained from cultures of the same mold (Penicillium notatum) which produces penicillin G (or "regular" penicillin). It differs from penicillin G in the method by which it is extracted, and is usually found more abundantly in flask-grown penicillin. We have tested the relative sensitivity of various bacteria to penicillin X and penicillin G and have found that two to 16 times as much penicillin G is required as penicillin X, unit for unit, to kill many bacteria in vitro. The details of this study will be published elsewhere. Other investigators1-3 have reported similar results. In
HIRSH HL, DOWLING HF, SWEET LK. TREATMENT OF VARIOUS INFECTIONS WITH PENICILLIN X, WITH A PRELIMINARY NOTE ON THE VALUE OF PENICILLIN X IN SCARLET FEVER1. Ann Intern Med. ;25:78–87. doi: 10.7326/0003-4819-25-1-78
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Published: Ann Intern Med. 1946;25(1):78-87.
Infectious Disease, Streptococcal Infections.
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