JOSEPH H. MORTON, M.D.; THOMAS H. MCGAVACK, M.D., F.A.C.P.
Much time and effort have been spent in the study of the probably complex interrelationship existing between the anterior pituitary and the pancreatic islets in their regulation of carbohydrate metabolism. Many points are still obscure. However, there is evidence for an over-all antagonistic action between the hypophysis and the islets of Langerhans which is well supported by the following data.
Hypophysectomy results in a marked improvement in the diabetic state of depancreatized animals,1, 2 and permanent diabetes can be induced by injecting extracts from the anterior pituitary.3, 4, 5, 6, 7 These facts indicate that a diabetogenic principle is formed
MORTON JH, MCGAVACK TH. THE INFLUENCE OF OVARIAN ACTIVITY AND ADMINISTERED ESTROGENS UPON DIABETES MELLITUS: CASE REPORT(THE INFLUENCE OF OVARIAN ACTIVITY AND ADMINISTERED ESTROGENS UPON DIABETES MELLITUS: CASE REPORT*). Ann Intern Med. 1946;25:154–161. doi: 10.7326/0003-4819-25-1-154
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Published: Ann Intern Med. 1946;25(1):154-161.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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