GEORGE C. GRIFFITH; ROBERT W. HUNTINGTON JR.
Abrupt cessation of heart beat, as distinguished from gradual failure, involves mechanisms of which we know little.1, 2 Sudden death occurring in this manner often finds no adequate pathologic explanation, although there is usually evidence of cardiac and aortic disease. In searching for a plausible general hypothesis, that of acute circulatory impairment in the heart, lungs, or brain-stem appears not unattractive. Although vascular occlusion by emboli, by thrombi forming in damaged areas, or by gradually progressing sclerosis has long engaged the attention of pathologists, awareness of functional vascular changes, in part, perhaps, referable to the autonomic nervous system3 of
GRIFFITH GC, HUNTINGTON RW. SUDDEN DEATH IN RHEUMATIC FEVER1. Ann Intern Med. ;25:283–292. doi: 10.7326/0003-4819-25-2-283
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Published: Ann Intern Med. 1946;25(2):283-292.
Infectious Disease, Rheumatology, Streptococcal Infections.
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