HARRISON F. FLIPPIN, M.D., F.A.C.P.; JOHN G. REINHOLD, Ph.D.; LILLIAN POLLACK; ELAINE CLAUSEN, B.A.
Renal complications due to sulfonamide therapy continue to be among the most frequent and serious attending the use of these drugs.1, 2, 3 Two main causes are established: (1) irritation due to formation in the kidneys or ureters of crystals largely of the acetylated drug and (2) nephrotoxic action. The causes of the latter are poorly understood. However, there is ample evidence to show that crystalluria is the result of the very low solubility of the acetylated drugs in urine that is acid in reaction.4, 5, 6, 7, 8 Despite numerous demonstrations of the effectiveness of alkalinization6, 9, 10, 11,
FLIPPIN HF, REINHOLD JG, POLLACK L, CLAUSEN E. AN EVALUATION OF SULFONAMIDE MIXTURES AND VARIOUS ADJUVANTS FOR CONTROL OF SULFONAMIDE CRYSTALLURIA(AN EVALUATION OF SULFONAMIDE MIXTURES AND VARIOUS ADJUVANTS FOR CONTROL OF SULFONAMIDE CRYSTALLURIA*). Ann Intern Med. 1946;25:433–442. doi: 10.7326/0003-4819-25-3-433
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Published: Ann Intern Med. 1946;25(3):433-442.
Hospital Medicine, Infectious Disease.
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