Anemia developing as a result of a diet deficient in vitamins has been described in a number of species of animals. One of the earliest observations was that of Wills and Bilimoria1 (1932). Monkeys fed a deficient diet similar to that customarily consumed by the poorer classes in India developed a macrocytic anemia, accompanied by leukopenia, granulocytopenia, and a megaloblastic hyperplasia of the bone marrow, which could be relieved by feeding marmite (yeast extract). This anemia closely resembled that seen in human cases of nutritional macrocytic anemia. This work has been confirmed and extended by subsequent observers, notably by Day
FOLIC ACID. Ann Intern Med. ;25:534–538. doi: 10.7326/0003-4819-25-3-534
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Published: Ann Intern Med. 1946;25(3):534-538.
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