J. LERMAN, M.D.; H. W. JONES, M.D.; E. CALKINS, M.D.
Our interest in the pathology and pathological physiology of cretinous goiters was stimulated by the discovery and study of two cretinous brothers, both possessing goiters. The results of this study, plus additional observations on two other cretinous subjects with goiter, on patients treated with thiouracil and on experimental animals, have been the basis of speculation regarding the rôle of hyperplasia in the genesis of neoplasia. Since studies of the type made on the two cretinous brothers are instructive, the results are presented below in detail, together with brief clinical histories.
Case 1. R. W., a 19 year old
J. LERMAN, H. W. JONES, E. CALKINS. STUDIES ON TWO SPORADIC CRETINOUS BROTHERS WITH GOITER, TOGETHER WITH SOME REMARKS ON THE RELATION OF HYPERPLASIA TO NEOPLASIA(STUDIES ON TWO SPORADIC CRETINOUS BROTHERS WITH GOITER, TOGETHER WITH SOME REMARKS ON THE RELATION OF HYPERPLASIA TO NEOPLASIA*). Ann Intern Med. 1946;25:677–701. doi: 10.7326/0003-4819-25-4-677
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Published: Ann Intern Med. 1946;25(4):677-701.
Endocrine and Metabolism, Hematology/Oncology, Thyroid Disorders.
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