SOLOMON BEN-ASHER, M.D.
Since the introduction of novarsurol as a diuretic by Saxl and Heilig1 in 1923, dehydration by means of the mercurial has played an important rôle in the treatment of congestive heart failure. Within recent years, however, instances of fatal and non-fatal reactions have been described in the literature. These reactions, though they occur infrequently, cause a great deal of apprehension when one has to resort to the use of the drug.
The literature on the toxic reactions to the mercurial diuretics published prior to 1942 has been adequately reviewed by DeGraff and Nadler.2 In 1944, Wexler and Ellis3 reported two
BEN-ASHER S. ON THE TOXICITY OF THE MERCURIAL DIURETICS: OBSERVATIONS ON EIGHTEEN CASES WITH SUGGESTIONS FOR THE PREVENTION OF TOXIC REACTIONS1. Ann Intern Med. ;25:711–724. doi: 10.7326/0003-4819-25-4-711
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Published: Ann Intern Med. 1946;25(4):711-724.
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