DAVID M. SPAIN, M. D.; THOMAS B. CLARK, M. D.
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As yet, there have been no reports of the occurrence of agranulocytosis resulting from the use of penicillin. As a matter of fact, penicillin is one of the most frequently used therapeutic agents in agranulocytosis in order to prevent or to combat the associated infection. The following case, although not conclusive, suggested that on rare occasions penicillin may produce agranulocytosis.
The patient, a 54 year old white male, was admitted on October 12, 1945, to the First Surgical Division of Bellevue Hospital with the complaint of abdominal pain of rive days' duration. He presented the classical symptoms and
SPAIN DM, CLARK TB. A CASE OF AGRANULOCYTOSIS OCCURRING DURING THE COURSE OF PENICILLIN THERAPY1. Ann Intern Med. ;25:732–733. doi: 10.7326/0003-4819-25-4-732
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Published: Ann Intern Med. 1946;25(4):732-733.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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