The intimate relationship of the spleen to hematopoiesis has been recognized for many years. This correlation has been exemplified in the past by the catch-all term splenic anemia formerly widely used to describe almost any syndrome characterized by splenomegaly and anemia. However, in contradistinction to the many recent advances in knowledge of the normal and pathological physiology of other organs and systems, information concerning the activities of the spleen has been relatively scanty. Such information as has accumulated has often been deduced from observations made in pathological states. The concept of hypersplenism is typical of this approach.
In 1916 Kaznelson1
THE CONCEPT OF HYPERSPLENISM. Ann Intern Med. ;25:868–870. doi: 10.7326/0003-4819-25-5-868
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Published: Ann Intern Med. 1946;25(5):868-870.
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