NORMAN H. ISAACSON, M.D.; PAUL RAPOPORT, M.D.
Ehrlich,20 in 1880, was the first to stain and definitely describe the eosinophile, though previous investigators29, 30 seem to have recognized the coarse granules in the unstained cells. Ehrlich believed that eosinophiles originated and matured in the bone marrow and were delivered into the circulating blood as a definite cell type. This concept is still considered to be correct.
Most hematologists21, 22, 23, 26 today agree that 6 per cent of the total white cell count is the upper limit of normal for eosinophilic leukocytes. Kirk24 recently made an extensive review of the literature on eosinophilia and reported an eosinophile
ISAACSON NH, RAPOPORT P. EOSINOPHILIA IN MALIGNANT TUMORS: ITS SIGNIFICANCE(EOSINOPHILIA IN MALIGNANT TUMORS: ITS SIGNIFICANCE*). Ann Intern Med. 1946;25:893–902. doi: 10.7326/0003-4819-25-6-893
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Published: Ann Intern Med. 1946;25(6):893-902.
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