The clinical usefulness of penicillin has been expanded through laboratory determinations of its antibacterial power in vitro and also through clinical trial in a great variety of infections in which there was frequently little reason to anticipate success. In the case of tetanus, studies in the laboratory have indicated that Clostridium tetani is affected by penicillin in fairly high dilutions. Abraham and his associates1 report complete inhibition of Clostridium tetani grown in Lemco broth at a dilution of 1,000,000. This figure is the same as that given for Staphylococcus aureus by the same authors. Organisms grown in beef broth were
LEWIS L. THERAPEUTIC TRIAL OF PENICILLIN IN TETANUS1. Ann Intern Med. 1946;25:903–915. doi: 10.7326/0003-4819-25-6-903
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Published: Ann Intern Med. 1946;25(6):903-915.
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