RICHARD A. GILBERT; JOSEPH W. GOLDZIEHER, M.D.
Aside from troublesome hypoglycemic reactions insulin is generally considered a rather innocuous drug in therapeutic dosage. Joslin1 and others2 have alluded to dangers of insulin therapy in patients with cardiac disease, but very little attention has been paid to these warnings, and insulin is often dispensed to older diabetics in a care-free and almost routine fashion. Büdingen,3 von Noorden4 and others were impressed even at an early period by dangerous and sometimes fatal cases of anginal syndrome following insulin therapy in aging diabetics. Gigon5 reported the sudden death of a diabetic with heart disease after the third injection of insulin.
GILBERT RA, GOLDZIEHER JW. THE MECHANISM AND PREVENTION OF CARDIOVASCULAR CHANGES DUE TO INSULIN1. Ann Intern Med. 1946;25:928–940. doi: 10.7326/0003-4819-25-6-928
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Published: Ann Intern Med. 1946;25(6):928-940.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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