HARRY F. DOWLING, M.D., F.A.C.P.; HUGH H. HUSSEY, M.D., F.A.C.P.; HAROLD L. HIRSH, M.D.; FRIEDA WILHELM, M.D.
Until the discovery of penicillin, sulfadiazine and several of its analogues were recognized universally as the drugs of choice in the treatment of pneumococcic pneumonia. When penicillin was shown to be active against pneumococci in vitro, the question of its relationship to the sulfonamides in the treatment of pneumococcic pneumonia became important. At first, since only small quantities of penicillin were available, this drug was reserved for patients who did not make the expected response to sulfonamides, but as the supply increased the problem of whether to treat all patients with penicillin from the start became paramount. In an attempt
DOWLING HF, HUSSEY HH, HIRSH HL, WILHELM F. PENICILLIN AND SULFADIAZINE, COMPARED WITH SULFADIAZINE ALONE, IN THE TREATMENT OF PNEUMOCOCCIC PNEUMONIA1. Ann Intern Med. ;25:950–956. doi: 10.7326/0003-4819-25-6-950
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Published: Ann Intern Med. 1946;25(6):950-956.
Infectious Disease, Pneumonia, Pulmonary/Critical Care.
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