EULYSS R. TROXLER, M.D.; DAVID NIEMETZ, M.D.
In recent literature there have appeared numerous case reports of lipoid granulomatosis or xanthomatosis with its varied clinical manifestations. Typical Hand-Schüller-Christian disease with its triad of symptoms, consisting of defects in membranous bones, exophthalmos and diabetes insipidus, is now considered as the craniohypophyseal localization of lipoid granulomatosis.1 On the basis of pathological studies, Green and Farber2 have concluded that eosinophilic or solitary granuloma of bone is one form of generalized xanthomatosis and not a new disease entity. These authors also describe Letterer-Siwe disease or reticulo-endotheliosis as the same pathological process seen in Hand-Schüller-Christian disease. Wherever there is reticulo-endothelium there can
TROXLER ER, NIEMETZ D. GENERALIZED XANTHOMATOSIS WITH PULMONARY, SKELETAL AND CEREBRAL MANIFESTATIONS: REPORT OF A CASE1. Ann Intern Med. ;25:960–968. doi: 10.7326/0003-4819-25-6-960
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Published: Ann Intern Med. 1946;25(6):960-968.
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