FREDA WILHELM, M.D.; HAROLD L. HIRSH, M.D.; HUGH H. HUSSEY, M.D., F.A.C.P.; HARRY F. DOWLING, M.D., F.A.C.P.
Prior to the use of penicillin, the establishment of a diagnosis of acute bacterial endocarditis was tantamount to prophesying the patient's death within one to six weeks. In the literature we have found reference to 40 patients with acute bacterial endocarditis who have been treated with penicillin (table 1).1, 12 Among the 25 patients whose infection was caused by a Staphylococcus aureus all but five died. Four of the patients with pneumococcic endocarditis died and two recovered. Five of the seven patients with hemolytic streptococcic endocarditis died, whereas death was reported in the case of one patient with gonococcic endocarditis.
WILHELM F, HIRSH HL, HUSSEY HH, DOWLING HF. THE TREATMENT OF ACUTE BACTERIAL ENDOCARDITIS WITH PENICILLIN1. Ann Intern Med. ;26:221–230. doi: 10.7326/0003-4819-26-2-221
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Published: Ann Intern Med. 1947;26(2):221-230.
Cardiology, Endocarditis, Infectious Disease.
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